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- Giving Up the Guns When a Family Member Has Alzheimer’s
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- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
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- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
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- Frailty May Increase Susceptibility to Alzheimer’s Disease
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- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
- Widely Used Office Dementia Tests Are Often Inaccurate
- Heart Rhythm Disorder, A-Fib, Tied to Dementia Risk
- Daytime Sleepiness Tied to Alzheimer’s Brain Changes
- Stress May Affect Memory and Brain Size
- Memory and Thinking Skills May Wane in Winter Months
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- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Music May Ease the Anxiety of Alzheimer’s
- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
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- How Exercise May Help Fend Off Alzheimer’s Disease
- 6 Months of Moderate Exercise Can Sharpen the Mind
- Foods for Brain Health? Try Leafy Greens, Red and Orange Veggies, Berries and Orange Juice
- To Drive or Not to Drive? Questions to Ask
- Exercise May Prevent Falls in Those with Alzheimer’s Disease
- The Driving and Car Key Dilemma of Alzheimer’s Disease
- Healthier Heart, Healthier Brain
- 2 Hours a Week of Exercise Can Boost Brain Health
- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
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- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
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Drug to treat Alzheimer’s is Ranked Highest
Aricept Ranks Highest Among Drugs to Treat Alzheimer’s
A new analysis that looked at four drugs currently approved to treat the mental decline of Alzheimer’s disease found that Aricept ranked highest in terms of easing cognitive decline. But all the drugs carry side effects, and some may be better for some people than others. And while the medications may ease symptoms for a time, none stop the relentless downward progression of the disease.
The study looked at the four currently approved drugs to treat the memory and thinking decline of Alzheimer’s: Aricept (generic name donepezil), Exelon (rivastigmine), Razadyne (galantamine) and Namenda (memantine). Aricept is most widely prescribed among the estimated 46 million people who have Alzheimer’s disease worldwide.
“Alzheimer’s dementia is the most common form of dementia in North America, and most people who have moderate to severe Alzheimer’s will be on these medications,” said Dr. Andrea Tricco, the lead author of the study and a scientist in the Li KaShing Knowledge Institute of St. Michael’s Hospital in Toronto. “This analysis will give both patients and clinicians a full picture of how each of these drugs will likely affect their cognition, as well as their overall health.”
For the study, researchers reviewed evidence from 142 clinical trials that evaluated the four drugs, alone or in combination. The review, published in the Journal of the American Geriatrics Society, looked at almost 34,000 patients over all.
Patients were assessed for memory, alertness, mood and concentration. Aricept ranked highest in terms of curbing the memory loss of Alzheimer’s disease as well as behavior and overall health.
People who took Aricept, however, were more likely to experience side effects including nausea, vomiting and diarrhea than those who received a dummy pill, according to the study.
Although no significant risk of serious harm, falls or reduced heart rate was associated with any of the medications in the study, the data was limited on these specific outcomes.
Previous research by the authors found that cognitive enhancers do not improve cognition or function in people with mild cognitive impairment, a serious form of memory loss that may progress to full-blown Alzheimer’s. These patients also experience significantly more nausea, diarrhea, vomiting and headaches while on the drugs.
The findings of the current study will help guide patients and clinicians who are making decisions about the best course of treatment for Alzheimer’s dementia, said Dr. Tricco.
“The more information we are able to gather about how each of these medications can affect a patient’s cognition and health, the more likely we are to be able to improve their health outcomes,” she said.
By www.ALZinfo.org, The Alzheimer’s Information Site. Reviewed by Marc Flajolet, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Andrea C. Tricco, Huda M. Ashoor, Charlene Soobiah, et al: “Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Metaanalysis.” Journal of the American Geriatrics Society, Sept. 29, 2017
