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- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
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- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
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- High Blood Sugar Tied to Memory Decline
- Blood Test for Alzheimer’s Gets Closer
- Worried About Your Memory? Alzheimer’s May Not Be to Blame
- Brain Changes of Menopause May Promote Alzheimer’s
- Predicting Who Will Get Alzheimer’s
- Personality Changes Are Not the Earliest Sign of Alzheimer’s
- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
- Being Too Thin Late in Life Tied to Increased Alzheimer’s Risk
- A Sniff Test for Alzheimer’s Getting Closer
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- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Insulin Nasal Spray Shows Promise as Alzheimer’s Treatment
- Inflammation Holds Clues to Alzheimer’s Progression, and Possible Treatment
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- Fitness in Midlife Tied to Lower Dementia Risk in Old Age
- Doctor’s Orders: Exercise for the Sake of Your Brain
- Positive Beliefs About Aging May Help Fend Off Alzheimer’s
- Brain Training May Help to Ward Off Dementia
- How Art Can Aid People With Alzheimer’s
- Music Can Be a Balm for People With Alzheimer’s Disease
- Crossword Puzzles May Help Keep the Brain Young
- 7 Steps for Optimal Brain Health
- Men, Women and Alzheimer’s Risk
- Exercise Vigorously and Often to Boost Brain Health
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
- World Alzheimer’s Month
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
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Drug to treat Alzheimer’s is Ranked Highest
Aricept Ranks Highest Among Drugs to Treat Alzheimer’s
A new analysis that looked at four drugs currently approved to treat the mental decline of Alzheimer’s disease found that Aricept ranked highest in terms of easing cognitive decline. But all the drugs carry side effects, and some may be better for some people than others. And while the medications may ease symptoms for a time, none stop the relentless downward progression of the disease.
The study looked at the four currently approved drugs to treat the memory and thinking decline of Alzheimer’s: Aricept (generic name donepezil), Exelon (rivastigmine), Razadyne (galantamine) and Namenda (memantine). Aricept is most widely prescribed among the estimated 46 million people who have Alzheimer’s disease worldwide.
“Alzheimer’s dementia is the most common form of dementia in North America, and most people who have moderate to severe Alzheimer’s will be on these medications,” said Dr. Andrea Tricco, the lead author of the study and a scientist in the Li KaShing Knowledge Institute of St. Michael’s Hospital in Toronto. “This analysis will give both patients and clinicians a full picture of how each of these drugs will likely affect their cognition, as well as their overall health.”
For the study, researchers reviewed evidence from 142 clinical trials that evaluated the four drugs, alone or in combination. The review, published in the Journal of the American Geriatrics Society, looked at almost 34,000 patients over all.
Patients were assessed for memory, alertness, mood and concentration. Aricept ranked highest in terms of curbing the memory loss of Alzheimer’s disease as well as behavior and overall health.
People who took Aricept, however, were more likely to experience side effects including nausea, vomiting and diarrhea than those who received a dummy pill, according to the study.
Although no significant risk of serious harm, falls or reduced heart rate was associated with any of the medications in the study, the data was limited on these specific outcomes.
Previous research by the authors found that cognitive enhancers do not improve cognition or function in people with mild cognitive impairment, a serious form of memory loss that may progress to full-blown Alzheimer’s. These patients also experience significantly more nausea, diarrhea, vomiting and headaches while on the drugs.
The findings of the current study will help guide patients and clinicians who are making decisions about the best course of treatment for Alzheimer’s dementia, said Dr. Tricco.
“The more information we are able to gather about how each of these medications can affect a patient’s cognition and health, the more likely we are to be able to improve their health outcomes,” she said.
By www.ALZinfo.org, The Alzheimer’s Information Site. Reviewed by Marc Flajolet, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Andrea C. Tricco, Huda M. Ashoor, Charlene Soobiah, et al: “Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Metaanalysis.” Journal of the American Geriatrics Society, Sept. 29, 2017
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