The Science of Brain Health
The human brain is a remarkable and complex organ that controls everything we do—from memory and movement to emotions and decision-making. Raising awareness about brain health and research is essential to better understand neurological disorders like Alzheimer’s disease and to advance efforts in prevention, treatment, and care.
Scientific organizations, educators, and community groups around the world engage in ongoing initiatives to help people of all ages learn more about the brain’s functions, its incredible capabilities, and the importance of supporting brain research. By increasing public understanding, we can drive more interest, funding, and progress toward healthier brains for all.

BRAIN FACTS
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The Devastating Effects of Alzheimer's Disease on Memory, Thinking, and Personality
People with Alzheimer's Disease gradually suffer memory loss and a decline in thinking abilities, as well as significant personality changes. These losses in cognitive function are accompanied by changes in the brain, including the build-up of amyloid plaques and tau-containing neurofibrillary tangles, which result in the death of brain cells and the breakdown of the connections between them.
The Healthy Brain vs. Alzheimer's Brain:
What You Need to Know

CEREBRUM: The main part of the brain filling most of the skull and consisting of two hemispheres. It is crucial for remembering, problem solving, thinking, feeling and movement.
CEREBRAL CORTEX (outer layer of the cerebrum): Interprets sensations, generates thoughts, participates in learning, memory and controls movement.
CEREBELLUM: Controls coordination and balance.
BRAIN STEM: Connects the brain to the spinal cord and controls breathing, digestion, heart rate and more.
CEREBRAL CORTEX: Due to widespread cell death, the cortex shrivels up, and individuals lose their ability to communicate, recognize family and friends and care for themselves.
NERVE CELLS AND TISSUES: Progressive cell and tissue death causes the brain to shrink dramatically and over time affects nearly all of a person’s functions.
HIPPOCAMPUS: Severe shrinking impairs the ability to form new memories.
VENTRICLES: Fluid-filled spaces grow larger due to brain cell death and brain shrinkage, leading to the ventricles expansion. The brain cell death causes thinking and reasoning problems, followed by difficulty in walking and loss of bladder control.
TANGLES: Abnormal, twisted clusters of proteins (e.g. Tau) that slowly prevent cells from functioning, which ultimately lead to cell death and can cause serious brain malfunctions.
PLAQUES: Abnormal aggregates of protein fragments (e.g. Abeta) that accumulate between cells, slowly perturbing most brain functions.
Every 65 seconds, someone in the United States is diagnosed with Alzheimer's disease, a debilitating condition that slowly erodes the mind and body. By donating to Alzheimer's research, you can make a significant difference in the lives of those affected by this devastating disease. Your contribution will help fund critical research to develop new treatments and, ultimately, find a cure. By taking action today, you can help bring us one step closer to a world without Alzheimer's. Donate now and make a difference in the fight against Alzheimer's.
LEARN MORE ABOUT THE BRAIN AND ALZHEIMER'S
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There’s been much in the media recently about artificial intelligence, or AI. Now scientists are using AI to spot previously unknown potential risk factors for Alzheimer’s disease.
Our Brains Are Getting Bigger!

Brain size is increasing with successive generations, according to a new report. Researchers found that people born in the 1970s had, on average, brain volumes that were 6.6 percent larger than those born in the 1930s.
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Eight heart-healthy habits in middle age may help to keep the brain in good working order for decades, researchers report.

