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- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
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- Alzheimer’s Caregivers May Benefit from Happiness Training
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- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
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- Air Pollution Tied to Alzheimer’s Brain Changes
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- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
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- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
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- Inflammation May Spur the Development of Alzheimer’s Disease
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- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
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- Obesity at Midlife Tied to Increased Dementia Risk
- Reading and Writing May Be Good for the Brain
- Ski Study Shows How Exercise May Aid the Brain
- How Light May Help People with Alzheimer’s Disease
- Trans Fats Tied to Increased Alzheimer’s Risk
- New Guidelines Urge a Healthy Lifestyle to Prevent Dementia
- At Genetic Risk for Alzheimer’s Disease? A Healthy Lifestyle May Help
- Exercise Can Help Keep the Brain ‘Young’
- Fighting Gum Disease May Aid in Fight Against Alzheimer’s Disease
- Brain Scans Aid in Management of Alzheimer’s Disease
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
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Spinal Tap May Help Detect Alzheimer’s Early
September 21, 2011
A protein found in the fluid that bathes the brain and spinal cord may help detect Alzheimer’s at an early stage, when treatment may be most effective.
“Being able to identify who will develop Alzheimer’s disease very early in the process will be crucial in the future,” said study author Robert Perneczky, M.D., of the Technical University Munich in Germany. “Once we have treatments that could prevent Alzheimer’s disease, we could begin to treat very early and hopefully prevent the loss of memory and thinking skills that occurs with this devastating disease.”
The researchers followed 58 people with mild cognitive impairment, a serious form of memory loss that sometimes progresses to Alzheimer’s disease. Measurements of the protein, called soluble amyloid precursor protein beta, or APP-beta, along with other measures was about 80 percent effective in predicting who went on to develop Alzheimer’s. The findings appeared in the journal Neurology, from the American Academy of Neurology.
All the participants underwent a spinal tap, also called a lumbar puncture, at the start of the study. The procedure involves the insertion of a needle in the lower back, using local anesthesia, to withdraw fluid from the spinal canal. Several proteins in the fluid were measured.
After three years, spinal taps were again done. At the time, 21 participants had developed Alzheimer’s disease, 27 still had mild cognitive impairment, two had developed a form of dementia other than Alzheimer’s, and eight had reverted back to healthy cognitive functioning.
Those men and women who developed Alzheimer’s had significantly higher levels of APP beta in their spinal fluid – 1,200 nanograms per milliliter of spinal fluid on average — than those who did not develop the disease — 932 nanograms per milliliter.
Measurement of soluble amyloid precursor protein beta, along with consideration of the patient’s age and levels of another protein called tau that collects in the brain in those with Alzheimer’s, predicted about four of every five people who would go on to develop Alzheimer’s. The results suggest that the soluble precursor protein “may be useful and superior to the established marker,” a protein called beta-amyloid, in the early diagnosis of Alzheimer’s disease, Dr. Perneczky said.
One reason why the precursor protein may be a better test than current methods is that it appears to be a very early step in the Alzheimer’s disease process. Therefore, it could be a good measure for detecting the earliest stages of the disease.
However, more work needs to be done to confirm the results. Scientists continue to study other markers and brain scans that may allow for early and more accurate Alzheimer’s diagnosis. Much more research needs to be done to confirm results and perfect techniques before doctors will be able to offer such tests routinely in the doctor’s office.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Perneczky R, et al “CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease” Neurology 2011; Vol. 77: pages 35-38, June 22, 2011.
