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- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
- Coordinated Care Lets Alzheimer’s Patients Stay at Home Longer
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- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
- Being Too Thin Late in Life Tied to Increased Alzheimer’s Risk
- A Sniff Test for Alzheimer’s Getting Closer
- Memory Complaints May Precede Alzheimer’s By Decades
- Alzheimer’s Brain Changes May Start Early in Life
- Getting a Clinical Diagnosis of Alzheimer’s May Have Safety Benefits
- Could Alzheimer’s Be Caused by a Brain Infection?
- Gene May Increase Risk for Both Alzheimer’s and Heart Disease
- Stress May Increase Your Risk of Developing Alzheimer’s Disease
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- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Insulin Nasal Spray Shows Promise as Alzheimer’s Treatment
- Inflammation Holds Clues to Alzheimer’s Progression, and Possible Treatment
- Common Allergy and Sleep Drugs Tied to Higher Alzheimer’s Risk
- Promising Drug, Gantenerumab, Fails to Prevent Alzheimer’s Onset
- Blood Test Offers Hope for Early Diagnosis of Alzheimer’s
- Brain ‘Pacemaker’ Is Being Tested for Alzheimer’s Disease
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- More Study Needed on Air Pollution’s Ties to Alzheimer’s
- One in Three Dementia Cases Could Be Prevented
- Good Dental Care Is Crucial for People With Alzheimer’s
- Poor Sleep May Add to Alzheimer’s Risk
- Healthy Heart, Healthy Brain
- Drinking Soda Tied to Poor Brain Health and Alzheimer’s Risk
- Diversified Mental Activity and Mental Challenges Can Keep the Mind Sharp in Old Age
- Mediterranean Diet Has Benefits for the Brain
- Dance to Keep the Brain in Shape
- Tablet Computer Apps Can Help Ease the Agitation of Alzheimer’s
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
- World Alzheimer’s Month
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- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease to the Effect of Gleevec
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
- Dr. Manny
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New Research from a Colleague of Our Medical Director
Dr. Paul Greengard and Dr. Sidney Strickland
Dr. Sidney Strickland is a recognized leader in the study of vascular factors and their effects on Alzheimer’s disease. A colleague of Dr. Paul Greengard, Director of the Fisher Center for Alzheimer’s Disease Research laboratory at The Rockefeller University, Dr. Strickland is head of the Laboratory of Neurobiology and Genetics and dean of graduate and postgraduate studies there.
Dr. Strickland and his team study the molecular mechanisms of nerve cell death and regeneration, with a special focus on Alzheimer’s disease. Preserving Your Memory spoke with Dr. Strickland about his research work.
PYM: Why is inflammation such an important consideration in brain health?
Dr. Sidney Strickland: Inflammation is a good process in most circumstances. It’s what the body uses to fight infection and tissue damage. But if it’s chronic and goes unchecked, it can be very deleterious. What we’ve uncovered is a process in Alzheimer’s disease that can lead to chronic inflammation, which can kill neurons and cause damage in the brain.
PYM: How do the beta-amyloid peptide and fibrinogen interact with each other?
SS: They have a physical interaction. Fibrinogen is the major protein component of blood clots. When the Alzheimer’s disease beta-amyloid peptide binds to fibrinogen, the clot that is formed is abnormal and hard to degrade. This persistent clot can promote the chronic inflammation that I mentioned earlier.
PYM: How does the beta-amyloid peptide affect the brain?
SS: It’s not exactly known how it affects the brain. That’s what everyone is looking for. Our results show that the beta-amyloid peptide can interact with clotting components and lead to persistent blood clots. In addition to persistent clots leading to chronic inflammation, they can lead to less blood flow to critical areas of the brain. If you don’t have blood flow to those areas, the tissues die. So persistent clots can create less blood flow and inflammation, and both those processes can end up killing cells.
PYM: What are the prospects for new Alzheimer’s disease treatments or therapies coming out of your research?
SS: This is one exciting aspect for us because there are new therapeutic strategies that evolve from our study. We don’t think there will be just one therapy for Alzheimer’s disease; there will probably be many therapies that attack various aspects of the disease. So if we could block the interaction of the beta-amyloid peptide with fibrinogen, it would prevent the formation of persistent clots, but it wouldn’t affect normal clotting. In this case, a person would not have bleeding tendencies, but would not have the formation of the beta-amyloid peptide-induced abnormal clots that can cause damage. We predict in this case that there would be beneficial effects on the cognitive dysfunction that characterizes Alzheimer’s disease.