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- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
- Susceptible to Scams? It May Be an Early Sign of Alzheimer’s Disease
- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
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- Depression Increases the Risk of Alzheimer’s Disease
- Poor Sleep Tied to Rise in Alzheimer’s Protein in Blood
- Air Pollution Tied to Alzheimer’s Brain Changes
- The Tau of Alzheimer’s
- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
- Frailty May Increase Susceptibility to Alzheimer’s Disease
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- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
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- Aerobic Exercise Shows Brain Benefits for Those at Risk of Alzheimer’s Disease
- Eating Flavonols, Found in Fruits, Vegetables and Tea, May Lower Alzheimer’s Risk
- Obesity at Midlife Tied to Increased Dementia Risk
- Reading and Writing May Be Good for the Brain
- Ski Study Shows How Exercise May Aid the Brain
- How Light May Help People with Alzheimer’s Disease
- Trans Fats Tied to Increased Alzheimer’s Risk
- New Guidelines Urge a Healthy Lifestyle to Prevent Dementia
- At Genetic Risk for Alzheimer’s Disease? A Healthy Lifestyle May Help
- Exercise Can Help Keep the Brain ‘Young’
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- Important Message from Us to You during COVID-19
- Lucretia V. Holden promoted to Executive Director at the Fisher Center
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
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Red Wine Ingredient, Resveratrol, Shows Hints of Promise for Alzheimer’s
December 15, 2015
High doses of an ingredient found in red wine and chocolate stabilized levels of a brain protein linked to the progression of Alzheimer’s disease, a preliminary trial found. The results suggest that the compound, called resveratrol, might have an effect on Alzheimer’s, but more study is needed to determine whether it might help to slow the progression of the disease.
The study, conducted at 21 medical centers across the country, examined the effects of a specially prepared resveratrol concentrate in 119 people with mild to moderate Alzheimer’s disease.
Study participants were divided into two groups. Half got increasing doses of a purified, high-dose form of resveratrol. The other group got a placebo dummy pill. The highest dose of resveratrol tested was one gram by mouth twice a day — equivalent to the amount found in about 1,000 bottles of red wine. The dose was much higher than that available in resveratrol supplements in health food stores, many of which also contain impurities (some act as powerful laxatives).
Over the course of a year, those who got the resveratrol showed stable blood and spinal fluid levels of a protein called beta-amyloid-40. The protein comes in various forms and is a hallmark of Alzheimer’s disease. As Alzheimer’s progresses, levels of beta-amyloid-40 typically decrease in the blood and spinal fluid, while increasing in the brain.
There was no proof that resveratrol improved memory in those who took it, though people in the resveratrol group had slight improvements in their ability to carry out daily tasks, such as remembering to brush their teeth.
While the results are promising, “we can’t conclude from this study that the effects of resveratrol treatment are beneficial,” said study leader Dr. R. Scott Turner, director of the Memory Disorders Program at Georgetown University Medical Center. “This is a single, small study with findings that call for further research to interpret properly.”
The high doses of resveratrol seemed to be generally safe and well tolerated; some people had digestive upset. The researchers are planning a larger study in the coming year. The findings appeared in the journal Neurology.
Resveratrol has been studied for a range of potential health benefits, perhaps most notably for its potential to extend lifespan. It appears to activate cell proteins known as sirtuins, the same proteins activated by severe calorie restriction. Whether resveratrol extends lifespans – or slows Alzheimer’s — in people remains unknown.
Resveratrol is a naturally occurring compound found in foods including grapes, red wine, blueberries and dark chocolate. If continued research shows the compound has benefits against Alzheimer’s, new drugs might be developed to better target the disease.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research at The Rockefeller University.
Source: R. Scott Turner, MD, PhD; Ronald G. Thomas, Ph,; Suzanne Craft, PhD, et al: “A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.” Neurology, published online Sept. 11, 2015
