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- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
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- Frailty May Increase Susceptibility to Alzheimer’s Disease
- Intensive Blood Pressure Control May Help Keep Memory Sharp
- Inflammation May Spur the Development of Alzheimer’s Disease
- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
- Widely Used Office Dementia Tests Are Often Inaccurate
- Heart Rhythm Disorder, A-Fib, Tied to Dementia Risk
- Daytime Sleepiness Tied to Alzheimer’s Brain Changes
- Stress May Affect Memory and Brain Size
- Memory and Thinking Skills May Wane in Winter Months
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- Experimental Drug, Fails to Benefit Alzheimer’s Patients
- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Music May Ease the Anxiety of Alzheimer’s
- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
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- Foods for Brain Health? Try Leafy Greens, Red and Orange Veggies, Berries and Orange Juice
- To Drive or Not to Drive? Questions to Ask
- Exercise May Prevent Falls in Those with Alzheimer’s Disease
- The Driving and Car Key Dilemma of Alzheimer’s Disease
- Healthier Heart, Healthier Brain
- 2 Hours a Week of Exercise Can Boost Brain Health
- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
- Beet Compound Shows Promise Against Alzheimer’s
- A Single Night of Not Sleeping Tied to Alzheimer’s Brain Changes
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- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
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- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
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Red Wine Ingredient, Resveratrol, Shows Hints of Promise for Alzheimer’s
High doses of an ingredient found in red wine and chocolate stabilized levels of a brain protein linked to the progression of Alzheimer’s disease, a preliminary trial found. The results suggest that the compound, called resveratrol, might have an effect on Alzheimer’s, but more study is needed to determine whether it might help to slow the progression of the disease.
The study, conducted at 21 medical centers across the country, examined the effects of a specially prepared resveratrol concentrate in 119 people with mild to moderate Alzheimer’s disease.
Study participants were divided into two groups. Half got increasing doses of a purified, high-dose form of resveratrol. The other group got a placebo dummy pill. The highest dose of resveratrol tested was one gram by mouth twice a day — equivalent to the amount found in about 1,000 bottles of red wine. The dose was much higher than that available in resveratrol supplements in health food stores, many of which also contain impurities (some act as powerful laxatives).
Over the course of a year, those who got the resveratrol showed stable blood and spinal fluid levels of a protein called beta-amyloid-40. The protein comes in various forms and is a hallmark of Alzheimer’s disease. As Alzheimer’s progresses, levels of beta-amyloid-40 typically decrease in the blood and spinal fluid, while increasing in the brain.
There was no proof that resveratrol improved memory in those who took it, though people in the resveratrol group had slight improvements in their ability to carry out daily tasks, such as remembering to brush their teeth.
While the results are promising, “we can’t conclude from this study that the effects of resveratrol treatment are beneficial,” said study leader Dr. R. Scott Turner, director of the Memory Disorders Program at Georgetown University Medical Center. “This is a single, small study with findings that call for further research to interpret properly.”
The high doses of resveratrol seemed to be generally safe and well tolerated; some people had digestive upset. The researchers are planning a larger study in the coming year. The findings appeared in the journal Neurology.
Resveratrol has been studied for a range of potential health benefits, perhaps most notably for its potential to extend lifespan. It appears to activate cell proteins known as sirtuins, the same proteins activated by severe calorie restriction. Whether resveratrol extends lifespans – or slows Alzheimer’s — in people remains unknown.
Resveratrol is a naturally occurring compound found in foods including grapes, red wine, blueberries and dark chocolate. If continued research shows the compound has benefits against Alzheimer’s, new drugs might be developed to better target the disease.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research at The Rockefeller University.
Source: R. Scott Turner, MD, PhD; Ronald G. Thomas, Ph,; Suzanne Craft, PhD, et al: “A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.” Neurology, published online Sept. 11, 2015
