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- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
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- Daytime Sleepiness May Be Early Warning Sign of Alzheimer’s
- Alzheimer’s Disease Increases the Risk of Falls
- High Blood Sugar Tied to Memory Decline
- Blood Test for Alzheimer’s Gets Closer
- Worried About Your Memory? Alzheimer’s May Not Be to Blame
- Brain Changes of Menopause May Promote Alzheimer’s
- Predicting Who Will Get Alzheimer’s
- Personality Changes Are Not the Earliest Sign of Alzheimer’s
- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
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- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Music May Ease the Anxiety of Alzheimer’s
- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
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- 2 Hours a Week of Exercise Can Boost Brain Health
- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
- Beet Compound Shows Promise Against Alzheimer’s
- A Single Night of Not Sleeping Tied to Alzheimer’s Brain Changes
- Should Alzheimer’s Patients Drink Coffee?
- Can a Salad a Day Help Keep Memory Sharp?
- Fitness in Midlife Tied to Lower Dementia Risk in Old Age
- Doctor’s Orders: Exercise for the Sake of Your Brain
- Positive Beliefs About Aging May Help Fend Off Alzheimer’s
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- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
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- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
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Plain Talk About Alzheimer’s Research
At the Fisher Center for Alzheimer’s Research Foundation, we are funding innovative Alzheimer’s research that is beginning to make serious headway. I wanted to talk to you not as a scientist, but as a regular guy originally from the Midwest, trying to help make sense of the new initiatives aimed at developing new Alzheimer’s treatments, taking place in the Fisher Center for Alzheimer’s Research laboratory.
What is Alzheimer’s disease?
Alzheimer’s is a progressive disease that destroys large areas of the brain over time, leaving its victims with little comprehension or awareness. Research indicates that the disease is associated with abnormal accumulations of proteins in the brain called plaques and tangles. A majority of scientists involved in Alzheimer’s research believe that abnormal accumulation of beta-amyloid is the main factor responsible for the degenerative changes that occur in the brain as the disease runs its course. Thus, drugs that lower beta-amyloid levels in the brain are expected to offer the most promising treatments.
What does that mean?
The lab we primarily fund is under the direction of Nobel laureate Dr. Paul Greengard. The Greengard lab team believes they can decode the mystery of Alzheimer’s by identifying a protein that can stop the unnatural buildup of beta-amyloid. Their plan is to isolate those cells that are resistant to beta-amyloid plaque and bring them into the lab, where they can find out why they are resistant and look for more effective treatments for people with Alzheimer’s.
How are they going to do that?
Previously, looking at the nature of cells required examining them one at a time. But the scientists at our lab recently developed a new tool called TRAP (translating ribosome affinity purification), which allows them to see the nature of many cells at once. Using TRAP, they are now able to analyze the subtle differences between cells that they couldn’t detect before to see which cells are more resistant to beta-amyloid plaque, and how they work in groups. This new information should point scientists in the direction of a protein that can help cells resist beta-amyloid plaques. Once that is located—and they are close to finding it now—they will be able to provide the fundamental information needed for drug companies to produce and develop effective Alzheimer’s treatments. This process offers the possibility of cutting a significant amount of time from the search for a cure.
What is being done now?
Along with our lab’s promising new discoveries, we are working to make sure our educational and awareness resources are the best we can offer. It is my greatest desire to offer a real sense of hope and show you how far we’ve come in our search for effective treatments and a cure. In fact, you can visit our website, www.ALZinfo.org, to read The Expert Review, where we publish scientifically reviewed Alzheimer’s news. There you can also learn about the stages of the disease and appropriate care, access our Facebook: Alzheimer’s and Dementia Support Group, and ask us any question you want through our Ask The Experts section. No question is too big or too small.
Kent L. Karosen
President & CEO of the Fisher Center for Alzheimer’s Research Foundation