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- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
- Susceptible to Scams? It May Be an Early Sign of Alzheimer’s Disease
- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
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- Depression Increases the Risk of Alzheimer’s Disease
- Poor Sleep Tied to Rise in Alzheimer’s Protein in Blood
- Air Pollution Tied to Alzheimer’s Brain Changes
- The Tau of Alzheimer’s
- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
- Frailty May Increase Susceptibility to Alzheimer’s Disease
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- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
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- A Daily Aspirin May Have Limited Brain Benefits
- For a Younger Brain, Try Walking, Gardening, Swimming or Dancing
- Moderate Drinking May Be Good for Your Brain
- Aerobic Exercise Shows Brain Benefits for Those at Risk of Alzheimer’s Disease
- Eating Flavonols, Found in Fruits, Vegetables and Tea, May Lower Alzheimer’s Risk
- Obesity at Midlife Tied to Increased Dementia Risk
- Reading and Writing May Be Good for the Brain
- Ski Study Shows How Exercise May Aid the Brain
- How Light May Help People with Alzheimer’s Disease
- Trans Fats Tied to Increased Alzheimer’s Risk
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- Important Message from Us to You during COVID-19
- Lucretia V. Holden promoted to Executive Director at the Fisher Center
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
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Plain Talk About Alzheimer’s Research
August 26, 2010
At the Fisher Center for Alzheimer’s Research Foundation, we are funding innovative Alzheimer’s research that is beginning to make serious headway. I wanted to talk to you not as a scientist, but as a regular guy originally from the Midwest, trying to help make sense of the new initiatives aimed at developing new Alzheimer’s treatments, taking place in the Fisher Center for Alzheimer’s Research laboratory.
What is Alzheimer’s disease?
Alzheimer’s is a progressive disease that destroys large areas of the brain over time, leaving its victims with little comprehension or awareness. Research indicates that the disease is associated with abnormal accumulations of proteins in the brain called plaques and tangles. A majority of scientists involved in Alzheimer’s research believe that abnormal accumulation of beta-amyloid is the main factor responsible for the degenerative changes that occur in the brain as the disease runs its course. Thus, drugs that lower beta-amyloid levels in the brain are expected to offer the most promising treatments.
What does that mean?
The lab we primarily fund is under the direction of Nobel laureate Dr. Paul Greengard. The Greengard lab team believes they can decode the mystery of Alzheimer’s by identifying a protein that can stop the unnatural buildup of beta-amyloid. Their plan is to isolate those cells that are resistant to beta-amyloid plaque and bring them into the lab, where they can find out why they are resistant and look for more effective treatments for people with Alzheimer’s.
How are they going to do that?
Previously, looking at the nature of cells required examining them one at a time. But the scientists at our lab recently developed a new tool called TRAP (translating ribosome affinity purification), which allows them to see the nature of many cells at once. Using TRAP, they are now able to analyze the subtle differences between cells that they couldn’t detect before to see which cells are more resistant to beta-amyloid plaque, and how they work in groups. This new information should point scientists in the direction of a protein that can help cells resist beta-amyloid plaques. Once that is located—and they are close to finding it now—they will be able to provide the fundamental information needed for drug companies to produce and develop effective Alzheimer’s treatments. This process offers the possibility of cutting a significant amount of time from the search for a cure.
What is being done now?
Along with our lab’s promising new discoveries, we are working to make sure our educational and awareness resources are the best we can offer. It is my greatest desire to offer a real sense of hope and show you how far we’ve come in our search for effective treatments and a cure. In fact, you can visit our website, www.ALZinfo.org, to read The Expert Review, where we publish scientifically reviewed Alzheimer’s news. There you can also learn about the stages of the disease and appropriate care, access our Facebook: Alzheimer’s and Dementia Support Group, and ask us any question you want through our Ask The Experts section. No question is too big or too small.
Kent L. Karosen
President & CEO of the Fisher Center for Alzheimer’s Research Foundation
