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- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
- Coordinated Care Lets Alzheimer’s Patients Stay at Home Longer
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- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
- Being Too Thin Late in Life Tied to Increased Alzheimer’s Risk
- A Sniff Test for Alzheimer’s Getting Closer
- Memory Complaints May Precede Alzheimer’s By Decades
- Alzheimer’s Brain Changes May Start Early in Life
- Getting a Clinical Diagnosis of Alzheimer’s May Have Safety Benefits
- Could Alzheimer’s Be Caused by a Brain Infection?
- Gene May Increase Risk for Both Alzheimer’s and Heart Disease
- Stress May Increase Your Risk of Developing Alzheimer’s Disease
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- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Insulin Nasal Spray Shows Promise as Alzheimer’s Treatment
- Inflammation Holds Clues to Alzheimer’s Progression, and Possible Treatment
- Common Allergy and Sleep Drugs Tied to Higher Alzheimer’s Risk
- Promising Drug, Gantenerumab, Fails to Prevent Alzheimer’s Onset
- Blood Test Offers Hope for Early Diagnosis of Alzheimer’s
- Brain ‘Pacemaker’ Is Being Tested for Alzheimer’s Disease
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- More Study Needed on Air Pollution’s Ties to Alzheimer’s
- One in Three Dementia Cases Could Be Prevented
- Good Dental Care Is Crucial for People With Alzheimer’s
- Poor Sleep May Add to Alzheimer’s Risk
- Healthy Heart, Healthy Brain
- Drinking Soda Tied to Poor Brain Health and Alzheimer’s Risk
- Diversified Mental Activity and Mental Challenges Can Keep the Mind Sharp in Old Age
- Mediterranean Diet Has Benefits for the Brain
- Dance to Keep the Brain in Shape
- Tablet Computer Apps Can Help Ease the Agitation of Alzheimer’s
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
- World Alzheimer’s Month
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- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease to the Effect of Gleevec
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
- Dr. Manny
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Fisher Scientists Discover Protein that Fuels Alzheimer’s Disease, Promising New Treatments Expected
Researchers at the Fisher Center for Alzheimer’s Research laboratory published “Gamma-secretase Activating Protein is a Therapeutic Target for Alzheimer’s Disease” in Nature online on September 1, 2010. Drs. Gen He (lead author) and Paul Greengard have discovered a protein that stimulates the production of beta-amyloid, and therefore represents a major new advance in Alzheimer’s disease research.
The protein, called gamma secretase activating protein (gSAP), is expected to become a major target for anti-amyloid drugs that inhibit the brain’s ability to produce toxic beta amyloid in Alzheimer’s disease. Beta-amyloid is a substance found in the brain that becomes toxic in Alzheimer’s disease and is responsible for most of the devastating symptoms of the disease. The researchers also discovered that gSAP is a target of the anti-cancer drug, Gleevec, which Fisher scientists previously showed could lower beta-amyloid levels in the brain. The new study showed that Gleevec lowers beta-amyloid production by binding to gSAP and preventing it from activating an enzyme called gamma secretase, which is responsible for producing beta-amyloid. In addition, the researchers showed that the inhibition of gSAP is not toxic to nerve cells, unlike many other experimental beta-amyloid inhibitor drugs that produce severe toxic reactions. Hence, gSAP holds the promise of discovering highly specific anti-beta-amyloid drugs that will be safe to patients.
“Millions of people suffer from Alzheimer’s disease, and treatment options are limited,” says Dr. Paul Greengard, Nobel Laureate and Director of the Fisher Center for Alzheimer’s Research laboratory at The Rockefeller University. “Existing drugs may mask symptoms for a time but do nothing to stop the relentless downward progression of Alzheimer’s. What is needed are safe and effective medications that will halt the cause of the underlying disease. It is our hope that this gamma secretase activating protein will greatly add to the creation of safe and effective Alzheimer’s treatments.”
Kent Karosen, President of the Fisher Center for Alzheimer’s Research Foundation says, “We are so proud of the scientists we support, and would like to specifically congratulate Drs. He and Greengard for discovering this important protein. Their latest research is a potential paradigm shift in how scientists and doctors around the world will attack Alzheimer’s.”
The Fisher Center for Alzheimer’s Research Foundation is a leading source of funding for Alzheimer’s research and education. We serve Alzheimer’s patients and their families by seeking to understand the causes of, discover a cure for, and improve the lives of people with Alzheimer’s disease. Nobel laureate Dr. Paul Greengard directs the Foundation’s team of internationally renowned scientists, who have been at the forefront of research providing the conceptual framework for understanding Alzheimer’s disease. The Fisher Center for Alzheimer’s Research Foundation actively raises funds for Alzheimer’s for these purposes. Of the money raised by the Foundation, only 9 cents out of every dollar is used for overhead and administrative purposes. For more information about the Fisher Center for Alzheimer’s Research Foundation, click: About Us
Contact:
Cory Ryan: [email protected], 800-259-4636
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