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- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
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- Inflammation May Spur the Development of Alzheimer’s Disease
- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
- Widely Used Office Dementia Tests Are Often Inaccurate
- Heart Rhythm Disorder, A-Fib, Tied to Dementia Risk
- Daytime Sleepiness Tied to Alzheimer’s Brain Changes
- Stress May Affect Memory and Brain Size
- Memory and Thinking Skills May Wane in Winter Months
- High Blood Pressure at Age 50 Tied to Dementia Later in Life
- High Fat, High Sugar Diet Tied to Alzheimer’s Brain Changes
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- Experimental Drug, Fails to Benefit Alzheimer’s Patients
- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Music May Ease the Anxiety of Alzheimer’s
- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
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- Foods for Brain Health? Try Leafy Greens, Red and Orange Veggies, Berries and Orange Juice
- To Drive or Not to Drive? Questions to Ask
- Exercise May Prevent Falls in Those with Alzheimer’s Disease
- The Driving and Car Key Dilemma of Alzheimer’s Disease
- Healthier Heart, Healthier Brain
- 2 Hours a Week of Exercise Can Boost Brain Health
- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
- Beet Compound Shows Promise Against Alzheimer’s
- A Single Night of Not Sleeping Tied to Alzheimer’s Brain Changes
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- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
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- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
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Three Drugs to Be Tested to Prevent Alzheimer’s
Scientists have chosen three drugs to be tested as a way to prevent the onset of Alzheimer’s disease in people who are genetically predisposed to get the disease at an early age. If one or more of the medications prove to be effective, the hope is that they may also provide benefits for the millions more people at high risk of developing the far more common late-onset form of Alzheimer’s.
Current Alzheimer’s medications may ease symptoms for a time but do not stem the underlying progression of disease or prevent its onset. These new drugs, under investigation, are targeted at preventing the memory loss and thinking problems of Alzheimer’s from occurring in the first place. The study will be conducted at medical centers in the U.S., Europe and Australia starting in 2013.
“Trying to prevent Alzheimer’s symptoms from ever occurring is a new strategy,” says Dr. John C. Morris, a professor at Washington University School of Medicine, which is leading the study.
The study will test the drugs in 160 volunteers who have one of several genes that cause early-onset Alzheimer’s. People who inherit such genes typically begin to show signs of dementia at an early age, typically younger than 50. Carrying such genes leads to Alzheimer’s in 100 percent of cases, unlike the APOE gene that can raise the risk of late-onset Alzheimer’s but does not guarantee you will get the disease.
The three drugs undergoing testing are designed to combat the toxic effects of beta-amyloid, the toxic protein that builds up and forms plaques in the brains of those with Alzheimer’s. Each works in different ways. The drugs are:
*Gantenerumab, an antibody that attaches to beta-amyloid and helps to remove it from the brain.
*Solanezumab, which binds to beta-amyloid before it clumps together, inhibits the plaque formation process.
* LY2886721, a drug that blocks an enzyme, beta-secretase, which is critical for beta-amyloid formation, thereby reducing the amount of beta-amyloid produced in the first place.
Earlier studies have shown them to be generally safe, with some hints that they may have benefits against Alzheimer’s. A recent analysis of data on solanezumab, for example, found that while the drug did not meet the study’s goals, it might slow memory loss in those with very mild Alzheimer’s.
For the prevention study, participants will be started on one of the three drugs, or a placebo, years before signs of memory loss or thought problems have appeared. At this early stage, the effects of the disease process on the brain are likely to be minimal. The hope is that by starting early, before brain damage has taken root, the drugs may stave off future development of symptoms. Eighty volunteers who do not have the genes will also participate as controls.
“In most trials in Alzheimer’s disease, people are treating the disease after the damage is being done to the brain,” said study leader Dr. Randall Bateman of Washington University. “And in this trial we’re trying to treat the disease before that damage gets done.”
Participants will receive scans and tests to look for signs of brain plaques and levels of beta-amyloid in the blood and spinal fluid. Such markers are an indication that Alzheimer’s disease is progressing, even if symptoms like memory loss are not evident. Scientists will monitor these markers to see whether the new treatments may be working to slow to stop the disease.
The first part of the trial, being conducted by a research partnership known as the Dominantly Inherited Alzheimer’s Network, or DIAN, is expected to last for two years. If it appears one or more of the drugs are working, volunteers will be switched to those drugs, and the trial will likely be expanded. For more information, visit www.Dian-Info.org.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Washington University School of Medicine. Dominantly Inherited Alzheimer’s Network (DIAN-Info.org).