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- Stress May Increase Your Alzheimer’s Risk; Take Steps to Reduce It
- Sleeping Pills May Increase Your Dementia Risk
- Poor Vision May Increase Your Risk of Dementia
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
- Susceptible to Scams? It May Be an Early Sign of Alzheimer’s Disease
- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
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- ‘A4’ Study Links Beta-Amyloid to Early Alzheimer’s
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- Depression Increases the Risk of Alzheimer’s Disease
- Poor Sleep Tied to Rise in Alzheimer’s Protein in Blood
- Air Pollution Tied to Alzheimer’s Brain Changes
- The Tau of Alzheimer’s
- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
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- A Reminder to Keep Taking Your Blood Pressure Medications
- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
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- Modest Amounts of Fruits and Vegetables May Lower Your Alzheimer’s Risk
- Processed Meat and Starchy Foods, Particularly in Combination, May Raise Dementia Risk
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- A Daily Aspirin May Have Limited Brain Benefits
- For a Younger Brain, Try Walking, Gardening, Swimming or Dancing
- Moderate Drinking May Be Good for Your Brain
- Aerobic Exercise Shows Brain Benefits for Those at Risk of Alzheimer’s Disease
- Eating Flavonols, Found in Fruits, Vegetables and Tea, May Lower Alzheimer’s Risk
- Obesity at Midlife Tied to Increased Dementia Risk
- Reading and Writing May Be Good for the Brain
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- Fisher Center in Top 1% of Charities Again
- Important Message from Us to You during COVID-19
- Lucretia V. Holden promoted to Executive Director at the Fisher Center
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
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Novel Treatments Could Slow Alzheimer’s Progression
July 5, 2005
July 5, 2005
A new drug, an immune system booster, and a medication used to treat diabetes showed promise in stemming the decline of Alzheimer’s disease, several small studies presented at a conference in Washington, D.C. suggest. Although it will require several years of additional testing in many more people, the findings point to the importance of ongoing and emerging research in the search for a cure for Alzheimer’s disease.
In one study, researchers at the University of Bristol in England tested an experimental drug called Flurizan in 207 people with mild to moderate Alzheimer’s disease. Half the study participants got the medication, while the others received a look-alike placebo . The drug is a revamped version of an older painkiller called flurbiprofen that has been shown to lower levels of a particularly toxic form of beta-amyloid, a substance that builds up in the brains of those with Alzheimer’s.
After a year, those men and women who had the highest doses of Flurizan in their bloodstream were, as a group, better able to carry out daily tasks. On tests that measure memory and reasoning, however, they did not show any significant improvements compared to those taking a placebo.
In a second study, investigators at The Weill Medical College of Cornell University in New York City gave injections of an immune system booster called immune globulin to eight people with Alzheimer’s. The drug contains a cocktail of proteins called antibodies that, researchers hope, may help mop up excess beta-amyloid in brains affected by the disease. The researchers found that the injections reduced the amount of beta-amyloid circulating in brain fluids. Preliminary tests also suggested some improvement in mental reasoning and memory, although the researchers stress that the study was much too small to draw firm conclusions about the potential effectiveness of this treatment approach.
In a third study, researchers at the University of Washington and Veterans Affairs Puget Sound Medical Center in Seattle tested a nasal spray containing insulin, the hormone that helps keep blood sugar levels in check in people with diabetes, in 26 people with Alzheimer’s. Some researchers suspect that insulin may boost brain cell function, and that some people with Alzheimer’s may be lacking in the hormone. The insulin nasal spray improved memory and recall in about half those who received it.
Larger studies of these and other therapies are planned. At this stage, it is far too early to recommend any of these medicines as a treatment of Alzheimer’s disease. Research on large groups of people needs to be done to determine if they are truly effective and safe.
The findings, though, underline the importance of continued support and funding for new Alzheimer’s treatments. The Fisher Center for Alzheimer’s Research Foundation plays a key role in working toward a cure for the devastating disease. Your contributions go directly to fund critical scientific and clinical research that improves life for those afflicted with Alzheimer’s and those who care for them. For more on how you can help and how the Fisher Center is reaching out, visit www.ALZinfo.org.
By www.ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source:
Alzheimer’s Association, International Conference on the Prevention of Dementia, June 20, Washington, D.C.
