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Article Title
- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
- Susceptible to Scams? It May Be an Early Sign of Alzheimer’s Disease
- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
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- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
- Frailty May Increase Susceptibility to Alzheimer’s Disease
- Intensive Blood Pressure Control May Help Keep Memory Sharp
- Inflammation May Spur the Development of Alzheimer’s Disease
- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
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- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
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- Trans Fats Tied to Increased Alzheimer’s Risk
- New Guidelines Urge a Healthy Lifestyle to Prevent Dementia
- At Genetic Risk for Alzheimer’s Disease? A Healthy Lifestyle May Help
- Exercise Can Help Keep the Brain ‘Young’
- Fighting Gum Disease May Aid in Fight Against Alzheimer’s Disease
- Brain Scans Aid in Management of Alzheimer’s Disease
- For Brain Health, Choose Heart-Healthy Foods
- Keeping Physically and Mentally Active at Midlife May Cut Dementia Risk
- How Exercise May Help Fend Off Alzheimer’s Disease
- 6 Months of Moderate Exercise Can Sharpen the Mind
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
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Drug Facts: Cognex (tacrine)
August 3, 2010
Generic name: tacrine
Description
Available in 10 mg, 20 mg, 30 mg, and 40 mg capsules.
Why It’s Prescribed
To slow progression of symptoms during the early stages of Alzheimer’s. Because side effects can be severe, however, this drug is now rarely prescribed.
Who Benefits
Provides modest benefits in only about a third of people with mild to moderate Alzheimer’s. The disease will continue to progress despite treatment.
How it Works
Slows the breakdown of acetylcholine, a chemical that aids memory by transmitting messages between brain cells.
Dosage Guidelines
To start: 10 mg, four times a day. The dose may be increased to up to 40 mg four times a day.
Onset of Effect
Benefits, if any, may appear within several weeks of starting the drug.
Storage
Store in a tightly sealed container away from heat, moisture and light.
Missed Dose
Take as soon as you remember, or resume your normal schedule if your next dose is within two hours.
Long-term Use
See your doctor for regular tests and exams if you are taking this drug long term. The drug is taken long term and may move the clock back a few months, but the disease continues to progress. If the drug seems to stop working, your doctor may switch you to another Alzheimer’s drug.
Side Effects
Serious: Unsteadiness or clumsiness, severe vomiting, racing or pounding heartbeat, seizures, liver damage.
Most common: Nausea, vomiting.
Less common: Stomach pain or cramps, indigestions, sore or achy muscles, headaches, dizziness, loss of appetite, diarrhea, belching, rapid breathing, flushed skin, increased urination, insomnia, watery eyes or mouth, runny nose, swelling in the legs or feet.
Precautions & Special Concerns
You will need blood tests every couple weeks to check for signs of possible liver damage.
When to Call the Doctor
If you experience side effects or the drug seems to stop working.
In Case of Overdose: Symptoms & What to Do
Profuse sweating or salivation, seizures, muscle weakness, severe nausea or vomiting, rapid and weak pulse, slowed heartbeat, enlarged pupils in the eyes, irregular breathing. Call your doctor, emergency medical services, or poison control center immediately.
Drug Interactions
May interact with cimetidine, anti-inflammatory pain relievers, or theophylline. Antihistamines, antipsychotic drugs, and some drugs for incontinence may also diminish its effects, as may smoking (nicotine).
Food Interactions
No known food interactions. Avoid alcohol if you are taking this drug.
Disease Interactions
Consult your doctor if you have asthma, epilepsy or seizures, heart disease, an ulcer, bowel or liver disease, Parkinson’s disease, urinary tract problems, or have had a head injury.
Expert comment
“For some people with Alzheimer’s disease, this drug can lead to improvements that the family can see. In others, responses may only be detectable under special testing conditions, or there may be no measurable response at all. It is important that family members and physicians maintain realistic expectations for drug therapy and remember that, as with all current Alzheimer’s drugs, responses are generally only modest at best.” –Samuel E. Gandy, M.D., Ph.D., Scientific Advisory Board, Fisher Center for Alzheimer’s Research Foundation
