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- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
- Coordinated Care Lets Alzheimer’s Patients Stay at Home Longer
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- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
- Being Too Thin Late in Life Tied to Increased Alzheimer’s Risk
- A Sniff Test for Alzheimer’s Getting Closer
- Memory Complaints May Precede Alzheimer’s By Decades
- Alzheimer’s Brain Changes May Start Early in Life
- Getting a Clinical Diagnosis of Alzheimer’s May Have Safety Benefits
- Could Alzheimer’s Be Caused by a Brain Infection?
- Gene May Increase Risk for Both Alzheimer’s and Heart Disease
- Stress May Increase Your Risk of Developing Alzheimer’s Disease
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- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Insulin Nasal Spray Shows Promise as Alzheimer’s Treatment
- Inflammation Holds Clues to Alzheimer’s Progression, and Possible Treatment
- Common Allergy and Sleep Drugs Tied to Higher Alzheimer’s Risk
- Promising Drug, Gantenerumab, Fails to Prevent Alzheimer’s Onset
- Blood Test Offers Hope for Early Diagnosis of Alzheimer’s
- Brain ‘Pacemaker’ Is Being Tested for Alzheimer’s Disease
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- More Study Needed on Air Pollution’s Ties to Alzheimer’s
- One in Three Dementia Cases Could Be Prevented
- Good Dental Care Is Crucial for People With Alzheimer’s
- Poor Sleep May Add to Alzheimer’s Risk
- Healthy Heart, Healthy Brain
- Drinking Soda Tied to Poor Brain Health and Alzheimer’s Risk
- Diversified Mental Activity and Mental Challenges Can Keep the Mind Sharp in Old Age
- Mediterranean Diet Has Benefits for the Brain
- Dance to Keep the Brain in Shape
- Tablet Computer Apps Can Help Ease the Agitation of Alzheimer’s
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
- World Alzheimer’s Month
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- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease to the Effect of Gleevec
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
- Dr. Manny
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Drug Facts: Cognex (tacrine)
Generic name: tacrine
Description
Available in 10 mg, 20 mg, 30 mg, and 40 mg capsules.
Why It’s Prescribed
To slow progression of symptoms during the early stages of Alzheimer’s. Because side effects can be severe, however, this drug is now rarely prescribed.
Who Benefits
Provides modest benefits in only about a third of people with mild to moderate Alzheimer’s. The disease will continue to progress despite treatment.
How it Works
Slows the breakdown of acetylcholine, a chemical that aids memory by transmitting messages between brain cells.
Dosage Guidelines
To start: 10 mg, four times a day. The dose may be increased to up to 40 mg four times a day.
Onset of Effect
Benefits, if any, may appear within several weeks of starting the drug.
Storage
Store in a tightly sealed container away from heat, moisture and light.
Missed Dose
Take as soon as you remember, or resume your normal schedule if your next dose is within two hours.
Long-term Use
See your doctor for regular tests and exams if you are taking this drug long term. The drug is taken long term and may move the clock back a few months, but the disease continues to progress. If the drug seems to stop working, your doctor may switch you to another Alzheimer’s drug.
Side Effects
Serious: Unsteadiness or clumsiness, severe vomiting, racing or pounding heartbeat, seizures, liver damage.
Most common: Nausea, vomiting.
Less common: Stomach pain or cramps, indigestions, sore or achy muscles, headaches, dizziness, loss of appetite, diarrhea, belching, rapid breathing, flushed skin, increased urination, insomnia, watery eyes or mouth, runny nose, swelling in the legs or feet.
Precautions & Special Concerns
You will need blood tests every couple weeks to check for signs of possible liver damage.
When to Call the Doctor
If you experience side effects or the drug seems to stop working.
In Case of Overdose: Symptoms & What to Do
Profuse sweating or salivation, seizures, muscle weakness, severe nausea or vomiting, rapid and weak pulse, slowed heartbeat, enlarged pupils in the eyes, irregular breathing. Call your doctor, emergency medical services, or poison control center immediately.
Drug Interactions
May interact with cimetidine, anti-inflammatory pain relievers, or theophylline. Antihistamines, antipsychotic drugs, and some drugs for incontinence may also diminish its effects, as may smoking (nicotine).
Food Interactions
No known food interactions. Avoid alcohol if you are taking this drug.
Disease Interactions
Consult your doctor if you have asthma, epilepsy or seizures, heart disease, an ulcer, bowel or liver disease, Parkinson’s disease, urinary tract problems, or have had a head injury.
Expert comment
“For some people with Alzheimer’s disease, this drug can lead to improvements that the family can see. In others, responses may only be detectable under special testing conditions, or there may be no measurable response at all. It is important that family members and physicians maintain realistic expectations for drug therapy and remember that, as with all current Alzheimer’s drugs, responses are generally only modest at best.” –Samuel E. Gandy, M.D., Ph.D., Scientific Advisory Board, Fisher Center for Alzheimer’s Research Foundation
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