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Article Title
- Alzheimer’s Caregivers at Risk for Depression
- Inflammatory Bowel Disease May Put You at Risk for Alzheimer’s
- Why More Women Than Men Get Alzheimer’s Disease
- Stress May Increase Your Alzheimer’s Risk; Take Steps to Reduce It
- Sleeping Pills May Increase Your Dementia Risk
- Poor Vision May Increase Your Risk of Dementia
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
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- Being Overweight May Be Bad for Your Brain
- Heart Risks Tied to Increased Dementia Risks
- ‘A4’ Study Links Beta-Amyloid to Early Alzheimer’s
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- Depression Increases the Risk of Alzheimer’s Disease
- Poor Sleep Tied to Rise in Alzheimer’s Protein in Blood
- Air Pollution Tied to Alzheimer’s Brain Changes
- The Tau of Alzheimer’s
- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
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- A Reminder to Keep Taking Your Blood Pressure Medications
- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
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- Deep Sleep May Help Protect the Brain Against Alzheimer’s Onset
- Flu and Pneumonia Vaccines May Help Protect Against Alzheimer’s Disease
- Fish as Brain Food, Combating the Effects of Pollution
- 5 Ways to Lower Your Alzheimer’s Risk
- Modest Amounts of Fruits and Vegetables May Lower Your Alzheimer’s Risk
- Processed Meat and Starchy Foods, Particularly in Combination, May Raise Dementia Risk
- Stay Social! Being Alone Can Increase Your Alzheimer’s Risk
- A Daily Aspirin May Have Limited Brain Benefits
- For a Younger Brain, Try Walking, Gardening, Swimming or Dancing
- Moderate Drinking May Be Good for Your Brain
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- The Ups and Downs of New Treatments for Alzheimer’s Disease
- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
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- Fisher Center in Top 1% of Charities Again
- Important Message from Us to You during COVID-19
- Lucretia V. Holden promoted to Executive Director at the Fisher Center
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
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Drug Facts: Cognex (tacrine)
August 3, 2010
Generic name: tacrine
Description
Available in 10 mg, 20 mg, 30 mg, and 40 mg capsules.
Why It’s Prescribed
To slow progression of symptoms during the early stages of Alzheimer’s. Because side effects can be severe, however, this drug is now rarely prescribed.
Who Benefits
Provides modest benefits in only about a third of people with mild to moderate Alzheimer’s. The disease will continue to progress despite treatment.
How it Works
Slows the breakdown of acetylcholine, a chemical that aids memory by transmitting messages between brain cells.
Dosage Guidelines
To start: 10 mg, four times a day. The dose may be increased to up to 40 mg four times a day.
Onset of Effect
Benefits, if any, may appear within several weeks of starting the drug.
Storage
Store in a tightly sealed container away from heat, moisture and light.
Missed Dose
Take as soon as you remember, or resume your normal schedule if your next dose is within two hours.
Long-term Use
See your doctor for regular tests and exams if you are taking this drug long term. The drug is taken long term and may move the clock back a few months, but the disease continues to progress. If the drug seems to stop working, your doctor may switch you to another Alzheimer’s drug.
Side Effects
Serious: Unsteadiness or clumsiness, severe vomiting, racing or pounding heartbeat, seizures, liver damage.
Most common: Nausea, vomiting.
Less common: Stomach pain or cramps, indigestions, sore or achy muscles, headaches, dizziness, loss of appetite, diarrhea, belching, rapid breathing, flushed skin, increased urination, insomnia, watery eyes or mouth, runny nose, swelling in the legs or feet.
Precautions & Special Concerns
You will need blood tests every couple weeks to check for signs of possible liver damage.
When to Call the Doctor
If you experience side effects or the drug seems to stop working.
In Case of Overdose: Symptoms & What to Do
Profuse sweating or salivation, seizures, muscle weakness, severe nausea or vomiting, rapid and weak pulse, slowed heartbeat, enlarged pupils in the eyes, irregular breathing. Call your doctor, emergency medical services, or poison control center immediately.
Drug Interactions
May interact with cimetidine, anti-inflammatory pain relievers, or theophylline. Antihistamines, antipsychotic drugs, and some drugs for incontinence may also diminish its effects, as may smoking (nicotine).
Food Interactions
No known food interactions. Avoid alcohol if you are taking this drug.
Disease Interactions
Consult your doctor if you have asthma, epilepsy or seizures, heart disease, an ulcer, bowel or liver disease, Parkinson’s disease, urinary tract problems, or have had a head injury.
Expert comment
“For some people with Alzheimer’s disease, this drug can lead to improvements that the family can see. In others, responses may only be detectable under special testing conditions, or there may be no measurable response at all. It is important that family members and physicians maintain realistic expectations for drug therapy and remember that, as with all current Alzheimer’s drugs, responses are generally only modest at best.” –Samuel E. Gandy, M.D., Ph.D., Scientific Advisory Board, Fisher Center for Alzheimer’s Research Foundation
