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- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
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- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
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- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
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- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
- Frailty May Increase Susceptibility to Alzheimer’s Disease
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- Inflammation May Spur the Development of Alzheimer’s Disease
- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
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- Take Your Blood Pressure Meds. It May Reduce Your Alzheimer’s Risk.
- Drug Company to Pursue Approval of Aducanumab, New Drug for Alzheimer’s
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
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- Reading and Writing May Be Good for the Brain
- Ski Study Shows How Exercise May Aid the Brain
- How Light May Help People with Alzheimer’s Disease
- Trans Fats Tied to Increased Alzheimer’s Risk
- New Guidelines Urge a Healthy Lifestyle to Prevent Dementia
- At Genetic Risk for Alzheimer’s Disease? A Healthy Lifestyle May Help
- Exercise Can Help Keep the Brain ‘Young’
- Fighting Gum Disease May Aid in Fight Against Alzheimer’s Disease
- Brain Scans Aid in Management of Alzheimer’s Disease
- For Brain Health, Choose Heart-Healthy Foods
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- A Rare Genetic Mutation May Protect Against Alzheimer’s
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- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
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Early Alzheimer’s May Involve More Than Just Memory Loss
January 23, 2015
Depression, anxiety, irritability and changes in appetite are among the earliest symptoms of Alzheimer’s disease, and may occur even before serious memory problems become evident, a new study reports. The study adds to a growing body of evidence that Alzheimer’s is a multi-year process and that behavioral and mood changes, along with problems with memory and thinking skills, may begin years before a diagnosis of Alzheimer’s is made.
“While earlier studies have shown that an estimated 90 percent of people with Alzheimer’s experience behavioral or psychological symptoms such as depression, anxiety and agitation, this study suggests that these changes begin before people even have diagnosable dementia,” said study author Catherine M. Roe, of Washington University School of Medicine.
The study, published in Neurology, the medical journal of the American Academy of Neurology, looked at 2,416 people age 50 and older who had no cognitive problems at the study’s start. Participants were recruited from 34 Alzheimer’s disease centers across the United States.
The participants were followed for up to seven years. During that time, 1,198 people retained healthy memory and thinking skills. They were compared with 1,218 who developed Alzheimer’s or other forms of dementia.
The researchers found that symptoms of depression were likely to increase with aging, but that they were twice as likely in those later diagnosed with dementia. Thirty percent of people who would develop dementia had depression within the first four years of the study, compared to 15 percent of those who did not develop dementia
Those who went on to develop dementia were also more likely to develop behavioral and mood changes such as apathy, appetite changes and irritability sooner than those who remained dementia-free.
As Alzheimer’s progresses, behavioral problems like agitation, aggression and psychosis typically become more prominent. But this study shows that behavioral changes may occur in the earliest stages of Alzheimer’s.
“We still don’t know whether depression is a response to the psychological process of Alzheimer’s disease or a result of the same underlying changes in the brain,” Dr. Roe said. People who are developing memory problems may, understandably, become anxious, agitated or depressed because they feel that their mind is slipping. It is also possible that the same process that kills brain cells in Alzheimer’s disease may also trigger depression and other psychological problems. “More research is needed to identify the relationship between these two conditions,” Dr. Roe said.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Mary Clare Masters, MD, John C. Morris, MD, Catherine M. Roe, PhD: “Noncognitive” Symptoms of Early Alzheimer Disease: A Longitudinal Analysis. Neurology Vol. 84, pages 1-6, 2015.
