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- Giving Up the Guns When a Family Member Has Alzheimer’s
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- Memory and Thinking Skills May Wane in Winter Months
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- Experimental Drug, Fails to Benefit Alzheimer’s Patients
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- The Driving and Car Key Dilemma of Alzheimer’s Disease
- Healthier Heart, Healthier Brain
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- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
- Beet Compound Shows Promise Against Alzheimer’s
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- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
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- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
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- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
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Early Alzheimer’s May Involve More Than Just Memory Loss
Depression, anxiety, irritability and changes in appetite are among the earliest symptoms of Alzheimer’s disease, and may occur even before serious memory problems become evident, a new study reports. The study adds to a growing body of evidence that Alzheimer’s is a multi-year process and that behavioral and mood changes, along with problems with memory and thinking skills, may begin years before a diagnosis of Alzheimer’s is made.
“While earlier studies have shown that an estimated 90 percent of people with Alzheimer’s experience behavioral or psychological symptoms such as depression, anxiety and agitation, this study suggests that these changes begin before people even have diagnosable dementia,” said study author Catherine M. Roe, of Washington University School of Medicine.
The study, published in Neurology, the medical journal of the American Academy of Neurology, looked at 2,416 people age 50 and older who had no cognitive problems at the study’s start. Participants were recruited from 34 Alzheimer’s disease centers across the United States.
The participants were followed for up to seven years. During that time, 1,198 people retained healthy memory and thinking skills. They were compared with 1,218 who developed Alzheimer’s or other forms of dementia.
The researchers found that symptoms of depression were likely to increase with aging, but that they were twice as likely in those later diagnosed with dementia. Thirty percent of people who would develop dementia had depression within the first four years of the study, compared to 15 percent of those who did not develop dementia
Those who went on to develop dementia were also more likely to develop behavioral and mood changes such as apathy, appetite changes and irritability sooner than those who remained dementia-free.
As Alzheimer’s progresses, behavioral problems like agitation, aggression and psychosis typically become more prominent. But this study shows that behavioral changes may occur in the earliest stages of Alzheimer’s.
“We still don’t know whether depression is a response to the psychological process of Alzheimer’s disease or a result of the same underlying changes in the brain,” Dr. Roe said. People who are developing memory problems may, understandably, become anxious, agitated or depressed because they feel that their mind is slipping. It is also possible that the same process that kills brain cells in Alzheimer’s disease may also trigger depression and other psychological problems. “More research is needed to identify the relationship between these two conditions,” Dr. Roe said.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Mary Clare Masters, MD, John C. Morris, MD, Catherine M. Roe, PhD: “Noncognitive” Symptoms of Early Alzheimer Disease: A Longitudinal Analysis. Neurology Vol. 84, pages 1-6, 2015.
