Article Finder
Browse our vast collection of articles. Simply select a category on the left and find a list of related articles on the right.
Article Category
Article Title
- High or Low Blood Pressure May Raise the Risk of Dementia
- How Alcohol Might Affect Your Dementia Risk
- The Hidden Costs of Alzheimer’s Disease
- Susceptible to Scams? It May Be an Early Sign of Alzheimer’s Disease
- Alzheimer’s Caregivers May Benefit from Happiness Training
- Giving Up the Guns When a Family Member Has Alzheimer’s
- Care Management Program Is Reducing Need for Anti-anxiety Medication and Visits to the Hospital/Emergency Room
- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- FOR MORE ARTICLES CLICK HERE
- Anemia Tied to Alzheimer’s Risk
- ‘Squeezed’ Blood Vessels in the Brain May Contribute to Alzheimer’s Onset
- Hormone Therapy for Prostate Cancer Tied to Alzheimer’s Disease Risk
- Lack of Deep Sleep Tied to Alzheimer’s Brain Changes
- Inflammation in Middle Age Tied to Thinking and Memory Problems Later
- Frailty May Increase Susceptibility to Alzheimer’s Disease
- Intensive Blood Pressure Control May Help Keep Memory Sharp
- Inflammation May Spur the Development of Alzheimer’s Disease
- High Blood Pressure of Pregnancy Tied to Late-Life Dementia
- Heart Disease and Alzheimer’s Disease Share Genetic Links
- FOR MORE ARTICLES CLICK HERE
- Drugs May Not Be the Best Choice for Easing the Agitation of Alzheimer’s
- Alzheimer’s Drug May Lead to Life-Threatening Muscle Disease
- Opioid Painkillers Increase Pneumonia Risk in People With Alzheimer’s Disease
- Drug Companies Halt Trials of Aducanumab for Alzheimer’s Disease
- Diabetes Treatments May Help Ward Off Alzheimer’s Disease
- Can Mushrooms Help Your Memory?
- Buyer Beware: Dietary Supplement’s Won’t Cure Alzheimer’s Disease
- Experimental Drug, Fails to Benefit Alzheimer’s Patients
- New Drug Shows Promise for Alzheimer’s
- Pain Relievers Present Special Hazards in People With Alzheimer’s Disease
- FOR MORE ARTICLES CLICK HERE
- Trans Fats Tied to Increased Alzheimer’s Risk
- New Guidelines Urge a Healthy Lifestyle to Prevent Dementia
- At Genetic Risk for Alzheimer’s Disease? A Healthy Lifestyle May Help
- Exercise Can Help Keep the Brain ‘Young’
- Fighting Gum Disease May Aid in Fight Against Alzheimer’s Disease
- Brain Scans Aid in Management of Alzheimer’s Disease
- For Brain Health, Choose Heart-Healthy Foods
- Keeping Physically and Mentally Active at Midlife May Cut Dementia Risk
- How Exercise May Help Fend Off Alzheimer’s Disease
- 6 Months of Moderate Exercise Can Sharpen the Mind
- FOR MORE ARTICLES CLICK HERE
- A Rare Genetic Mutation May Protect Against Alzheimer’s
- Income Drops in Young Adulthood May Impair Brain Health
- Blood Test for Alzheimer’s Grows Closer
- Are We Getting Closer to an Alzheimer’s Vaccine?
- Why More Women Than Men Have Alzheimer’s Disease
- Scientists get a ‘total surprise’ and a promising new clue for how to cure Alzheimer’s
- Some 44 Million People Have Alzheimer’s Worldwide
- Nearly 14 Million Americans Will Have Alzheimer’s Disease by 2060
- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- FOR MORE ARTICLES CLICK HERE
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer’s Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer’s Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- FOR MORE ARTICLES CLICK HERE
Stress, Diabetes and Memory Loss
March 11, 2008
March 11, 2008
Americans with diabetes are at increased risk for Alzheimer’s disease, earlier studies show. Now, scientists studying rodents have linked the learning and memory declines to a stress hormone known as corticosterone. It is similar to the main stress hormone produced in humans, called cortisol.
A new National Institutes of Health study in diabetic rodents finds that increased levels of corticosterone disrupts the hippocampus, the region of the brain responsible for learning and short-term memory. The hormone is produced by the adrenal gland.
When the researchers gave the rodents drugs to reduce levels of the stress hormone, the hippocampus recovered its “plasticity,” the ability to build new cells and to compensate for injury and disease.
“This research in animal models is intriguing, suggesting the possibility of novel approaches in preventing and treating cognitive impairment by maintaining normal levels of glucocorticoids [stress hormones],” said Richard J. Hodes, M.D., director of the National Institute on Aging, which funded the study. “Further study will provide a better understanding of the often complex interplay between the nervous system, hormones and cognitive health.”
In people, production of the stress hormone cortisol involves a complex feedback loop between the hypothalamus and pituitary gland in the brain and the adrenal gland, located near the kidney. People with poorly controlled diabetes often produce excess cortisol.
To study the interaction between elevated stress hormones and the hippocampus, the researchers tested the cognitive abilities and examined the brain tissue in rats with diabetes. They found that diabetic animals had learning and memory problems when stress hormone levels were high. The stress hormones appeared to impair the ability of the brain to grow new cells and forge connections. Returning the levels to normal, however, reversed the negative impact on the hippocampus and restored learning and memory.
“This advance in our understanding of the physiological changes caused by excessive production of cortisol may eventually play a role in preventing and treating cognitive decline in diabetes,” said Dr. Mattson, who heads the National Institute on Aging’s Laboratory of Neurosciences, part of the National Institutes of Health.
The findings may also help explain the connection between stress-related mood disorders and diabetes found in human population studies, he noted.
About one in five people over age 65 has Type 2 diabetes, a chronic age-related ailment marked by poor control of blood sugar (glucose). Diabetes is especially common in older people who are overweight, though it is becoming increasingly common in younger persons as well.
Previous research suggests that diabetes may increase Alzheimer’s risk through various possible pathways. For example, diabetes damages blood vessels in many parts of the body. It may affect blood vessels in the brain as well, impairing blood flow and damaging critical brain functions, including those involving memory.
Poor control of blood sugar levels by the hormone insulin, a hallmark of diabetes, also affects the brain. For example, scientists at the Fisher Center for Alzheimer’s Research at The Rockefeller University produced evidence several years ago suggesting that unregulated insulin may raise levels of beta-amyloid, a toxic protein that builds up in the brains of those with Alzheimer’s.
This new research adds another possible culprit to the diabetes-Alzheimer’s link: stress hormones that play a critical role in the ability of the brain to function and regenerate.
Your chances of developing Type 2 diabetes can be lessened by lifestyle changes such as exercise and a heart-healthy diet. Many researchers suggest that developing heart-healthy habits may decrease the risk of Alzheimer’s disease.
It’s also important to note, however, that having diabetes does not mean that you will develop Alzheimer’s as you age. Rather, diabetes increases your risk for developing the disease. Similarly, many people who develop Alzheimer’s do not have diabetes. There appear to be many risk factors for Alzheimer’s disease, including genes, years of formal education, heart disease, strokes, being overweight, and more. Diabetes appears to be one more risk factor for this devastating illness.
By www.ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source:
Mark Mattson, Ph.D., Alexis M. Stranahan, et al: Nature Neuroscience. Feb. 17, 2008.