Dr. Bustos’s research led to the discovery that the phosphorylation of Presenilin 1 regulates the levels of beta-amyloid which suggests that the modulation of this phosphorylation is an attractive target for Alzheimer’s disease. Together with Dr. Flajolet, investigated the mechanisms underlying these discoveries in an attempt to uncover novel approaches to tackle the disease, which led to a series of results further validating the relevance for Alzheimer’s disease of a biological phenomenon used by the cells to remove cellular debris and unwanted materials called autophagy.