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Publications

Posted By alz01 On August 16, 2010 @ 11:16 pm In | No Comments

Dr. Barry Reisberg has over 300 publications listed to date.

Here are the 10 most recent publications:

1.  "Nonpharmacological Therapies in Alzheimer’s Disease: A Systematic Review of Efficacy" [1]. Dementia and Geriatric Cognitive Disorders; September 10, 2010.

Summary: Nonpharamacolgical Therapies Can Improve the Quality of Life of People with Alzheimer’s. There is a demonstrated efficacy of nonpharmacological interventions which could offer hope to caregivers and people with dementia. After conducting a systematic review of previous worldwide studies, researchers led by Barry Reisberg, MD, the clinical director of the Fisher Alzheimer’s Disease Education and Resources Program at New York University’s Langone School of Medicine, and some colleagues in Spain and the UK, have found that that nonpharmacological therapies (NPTs) can improve relevant outcomes, such as improved thinking, behavior and delay of institutionalization of patients with Alzheimer’s. Research published in Dementia and Geriatric Cognitive Disorders on September 10, 2010 reveals that therapies such as physical activities, behavioral interventions and cognitive training are useful, and potentially cost effective.

Dr. Reisberg explains, “Patients with Alzheimer’s can’t live without care, especially in the later stages. If we don’t intervene with cognitive behavioral and physical therapies, patients will develop physical problems, and ultimately, deformities as well as agitation. We must help patients through the various stages of Alzheimer’s so that their needs are managed. Comparatively little has been done to investigate non pharmaceutical resources and care strategies. But it is the caregiving that patients with Alzheimer’s disease rely on as the disease progresses. For the first time, we have comprehensively and systematically looked at these types of interventions and find them to point to efficacy for both patient and caregiver. Although current research is promising, much more research needs to be done which should result in very large payoffs in reduced societal burden and improved patient well being.”

1,313 candidates participated in the study and evaluated in 26 selected categories. The most significant results of the study concluded that persons with AD greatly benefited from cognitive stimulations, physical exercise, use of music, behavioral interventions and a multicomponent treatment (such as when use of light and massage therapy were provided).

For interventions with caregivers, the highest scores were found most helpful for caregiver support, multicomponent support (such as education and respite care) and cost effectiveness was proved when the components of care were assessed with both the caregiver and the individual with dementia.

The study is successful in helping to improve the quality of life and activities of daily living, overall improvement of mood, positive well being, avoidance of agitation, and aiding in the delay of institutionalization to help reduce costs associated with patient care. In conclusion, the benefits to persons with dementia, their carers and society may be great; the investments comparatively modest and potential savings for the economy may be substantial.

Note: this study does not report on or about treatments which can help ward off or prevent the onset of Alzheimer’s disease, rather how to best adapt a nonpharmacological treatment course of care for Alzheimer’s patients and their caregivers.

2.  "Outcome over seven years of healthy adults with and without subjective cognitive impairment [2]". Alzheimer's & Dementia. 2010; 6: 11. Reisberg, Barry; Shulman, Melanie B; Torossian, Carol; Leng, Ling; Zhu, Wei.

3. "Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimer's Pathology in MCI and AD [3]". Current Alzheimer research. 2010; 7: 280. Sabbagh, MN; Cooper, K; DeLange, J; Stoehr, JD; Thind, K; Lahti, T; Reisberg, B; Sue, L; Vedders, L; Fleming, SR; Beach, TG.

4. "A roadmap for the prevention of dementia II: Leon Thal Symposium 2008 [4]". Alzheimer's & Dementia. 2009; 5: 85. Khachaturian, Zaven S; Snyder, Peter J; Doody, Rachelle; Aisen, Paul; Comer, Meryl; Dwyer, John; Frank, Richard A; Holzapfel, Andrew; Khachaturian, Ara S; Korczyn, Amos D; Roses, Allen; Simpkins, James W; Schneider, Lon S; Albert, Marilyn S; Egge, Robert; Deves, Aaron; Ferris, Steven; Greenberg, Barry D; Johnson, Carl; Kukull, Walter A; Poirier, Judes; Schenk, Dale; Thies, William; Gauthier, Serge; Gilman, Sid; Bernick, Charles; Cummings, Jeffrey L; Fillit, Howard; Grundman, Michael; Kaye, Jeff; Mucke, Lennart; Reisberg, Barry; Sano, Mary; Pickeral, Oxana; Petersen, Ronald C; Mohs, Richard C; Carrillo, Maria; Corey-Bloom, Jody P; Foster, Norman L; Jacobsen, Steve; Lee, Virginia; Potter, William Z; Sabbagh, Marwan N; Salmon, David; Trojanowski, John Q; Wexler, Nancy; Bain, Lisa J.

5. "FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease [5]". European journal of nuclear medicine & molecular imaging. 2009; 36: 811. Mosconi, Lisa; Mistur, Rachel; Switalski, Remigiusz; Tsui, Wai Hon; Glodzik, Lidia; Li, Yi; Pirraglia, Elizabeth; De Santi, Susan; Reisberg, Barry; Wisniewski, Thomas; de Leon, Mony J.

6. "Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008 [6]." Subjective cognitive impairment as an antecedent of Alzheimer's dementia. Alzheimer's & Dementia. 2009; 5: 154. Reisberg, Barry; Shulman, Melanie B.

7. "Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC plus for Mild Cognitive Impairment Clinical Trials [7]". Alzheimer disease & associated disorders. 2009; 23: 260. Schneider, LS; Raman, R; Schmitt, FA; Doody, RS; Insel, P; Clark, CM; Morris, JC; Reisberg, B; Petersen, RC; Ferris, SH.

8. "An entorhinal cortex sulcal pattern is associated with Alzheimer's disease [8]". Human brain mapping. 2009; 30: 874. Zhan, Jiong; Brys, Miroslaw; Glodzik, Lidia; Tsui, Wai; Javier, Elizabeth; Wegiel, Jerzy; Kuchna, Izabela; Pirraglia, Elizabeth; Li, Yi; Mosconi, Lisa; Saint Louis, Leslie A; Switalski, Remigiusz; De Santi, Susan; Kim, Byeong C; Wisniewski, Thomas; Reisberg, Barry; Bobinski, Matthew; de Leon, Mony J.

9. "Co morbid diseases enhance the loss of cognition in the elderly [Abstract]". Journal of the American Geriatrics Society. 2008; 56: S104. Danji, K; Boksay, I; Boksay, E; Torossian, C; Reisberg, B.

10. "Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline [9]". Neuropsychology. 2008; 22: 469. De Santi, Susan; Pirraglia, Elizabeth; Barr, William; Babb, James; Williams, Schantel; Rogers, Kimberley; Glodzik, Lidia; Brys, Miroslaw; Mosconi, Lisa; Reisberg, Barry; Ferris, Steven; de Leon, Mony J.

 

Click here for the full list of publications. [10]


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URLs in this post:

[1] "Nonpharmacological Therapies in Alzheimer’s Disease: A Systematic Review of Efficacy": http://www.alzinfo.org/10/about-alzheimers/nonpharmacological-therapies-alzheimers-disease-systematic-review-efficacy

[2] Outcome over seven years of healthy adults with and without subjective cognitive impairment: http://www.ncbi.nlm.nih.gov/pubmed/20129317

[3] Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimer's Pathology in MCI and AD: http://www.ncbi.nlm.nih.gov/pubmed/19715548

[4] A roadmap for the prevention of dementia II: Leon Thal Symposium 2008: http://www.ncbi.nlm.nih.gov/pubmed/19328434

[5] FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease: http://www.ncbi.nlm.nih.gov/pubmed/19142633

[6] Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008: http://www.ncbi.nlm.nih.gov/pubmed/19328438

[7] Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC plus for Mild Cognitive Impairment Clinical Trials: http://europepmc.org/articles/PMC2762354/reload=0;jsessionid=5BneLXEz9ma1HjDe1cQA.6

[8] An entorhinal cortex sulcal pattern is associated with Alzheimer's disease: http://www.ncbi.nlm.nih.gov/pubmed/18381771

[9] Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline: http://www.ncbi.nlm.nih.gov/pubmed/18590359

[10] Click here for the full list of publications.: http://www.med.nyu.edu/pubs/reisbb01.html

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