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Home > About Alzheimer's and Dementia > Understanding Alzheimer's Disease > Dementia Lewy Bodies

Dementia with Lewy Bodies

Dementia with Lewy bodies (DLB) is one of the most common types of progressive dementia. The central feature of DLB is progressive cognitive decline, combined with three additional defining features:  (1) pronounced “fluctuations” in alertness the and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations;  and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement.   People may also suffer from depression.  The symptoms of DLB are caused by the build-up of Lewy bodies – accumulated bits of alpha-synuclein protein -- inside the nuclei of neurons in areas of the brain that control particular aspects of memory and motor control.  The similarity of symptoms between DLB and Parkinson’s disease, and between DLB and Alzheimer’s disease, can often make it difficult for a doctor to make a definitive diagnosis. In addition, Lewy bodies are often also found in the brains of people with Parkinson's and Alzheimer’s diseases.  These findings suggest that either DLB is related to these other causes of dementia or that an individual can have both diseases at the same time.  DLB usually occurs sporadically, in people with no known family history of the disease. However, rare familial cases have occasionally been reported.

Other types of Dementias

 Creutzfeldt-Jakob Disease (CJD)

 Frontotemporal Dementia

 Huntington's Disease

 Normal Pressure Hydrocephalus

 Parkinson's Disease

 Vascular Dementia

 Wernicke-Korsakoff Syndromep

 
 
 

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This project was supported, in part, by a grant, number 90AZ2791, from the Administration on Aging, Department of Health and Human Services, Washington, D.C. 20201. Grantees undertaking projects under government sponsorship are encouraged to express freely their findings and conclusions. Points of view or opinions do not, therefore, necessarily represent official Administration on Aging policy.