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- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
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- High Blood Sugar Tied to Memory Decline
- Blood Test for Alzheimer’s Gets Closer
- Worried About Your Memory? Alzheimer’s May Not Be to Blame
- Brain Changes of Menopause May Promote Alzheimer’s
- Predicting Who Will Get Alzheimer’s
- Personality Changes Are Not the Earliest Sign of Alzheimer’s
- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
- Being Too Thin Late in Life Tied to Increased Alzheimer’s Risk
- A Sniff Test for Alzheimer’s Getting Closer
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- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Insulin Nasal Spray Shows Promise as Alzheimer’s Treatment
- Inflammation Holds Clues to Alzheimer’s Progression, and Possible Treatment
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- Fitness in Midlife Tied to Lower Dementia Risk in Old Age
- Doctor’s Orders: Exercise for the Sake of Your Brain
- Positive Beliefs About Aging May Help Fend Off Alzheimer’s
- Brain Training May Help to Ward Off Dementia
- How Art Can Aid People With Alzheimer’s
- Music Can Be a Balm for People With Alzheimer’s Disease
- Crossword Puzzles May Help Keep the Brain Young
- 7 Steps for Optimal Brain Health
- Men, Women and Alzheimer’s Risk
- Exercise Vigorously and Often to Boost Brain Health
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- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
- World Alzheimer’s Month
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
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Paying Attention to Blood Vessel Health in Alzheimer’s Disease
People with Alzheimer’s disease often have problems with blood vessels in the brain that may be making symptoms worse, a new study reports. The findings may help to explain why measures that can improve blood vessel health in midlife — like eating a heart-healthy diet, getting regular exercise and keeping cholesterol levels in check —may help to curb Alzheimer’s in old age.
While strokes and blood vessel disease are commonly recognized causes of dementia other than Alzheimer’s, the study provides additional evidence that blood vessel disease likely plays an important role in many cases of Alzheimer’s as well. People who have signs of both Alzheimer’s and blood vessel or vascular disease are sometimes referred to as having “mixed” dementia.
The findings, published in the journal Brain, come from researchers at the Perelman School of Medicine at the University of Pennsylvania who looked at vascular health across a wide range of brain ailments. They found that limited blood flow to the brain played a role in many brain disorders, including Parkinson’s disease and Lou Gehrig’s disease (also known as ALS). But compared to these conditions, vascular disease was far more common among people with Alzheimer’s
“While there was evidence already to suggest that vascular disease could play a role in neurodegenerative disease, this is the first study to compare the burden of vascular disease across neurodegenerative diseases with multiple, distinct or different origins,” said senior author Dr. John Q. Trojanowski, director of the Alzheimer’s Disease Core Center at the University of Pennsylvania. “We were surprised to find such a strong link to vascular disease in Alzheimer’s disease, especially in younger patients, in comparison to individuals with other neurodegenerative diseases.”
For the study, the researchers analyzed 5,715 cases from the ongoing National Alzheimer’s Coordinating Center database, which has been collecting data about Alzheimer’s cases across the country. Almost 80 percent of the Alzheimer’s disease patients showed some degree of blood vessel problems. Problems ranged from hardening of the arteries, blocked or narrowed blood vessels, to+ bleeding in the brain.
“In the absence of any disease modifying therapies to change the course of Alzheimer’s, we hope that the diligent use of existing treatments for vascular conditions and the implementation of campaigns promoting healthy lifestyles in young and middle aged people may have a positive impact on preventing or reducing dementia symptoms in Alzheimer’s and Parkinson’s disease ” said Dr. Jon B. Toledo, a study author.
The authors note that many drugs being aimed at Alzheimer’s are targeted at beta-amyloid, the toxic protein that builds up in the brains of patients with the disease. But it may be important to take into account problems related to poor blood flow as well, they say, and to include such patients in future studies of Alzheimer’s treatments.
By ALZinfo.org, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: JB Toledo, SE Arnold, K Raible, et al: “Contribution of Cerebrovascular Disease in Autopsy Confirmed Neurodegenerative Disease Cases in the National Alzheimer’s Coordinating Centre.” Brain, epub ahead of print, July 10, 2013.