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Friends and Family May Be the Best Detectors of Early Alzheimer’s

Family members and friends may be better judges of early Alzheimer’s disease than standard memory tests, a new study reports. The results could help doctors diagnose suspected Alzheimer’s at an earlier stage, when treatment may be more effective and families can better prepare for the changes to come.

The study comes from Washington University School of Medicine in St. Louis, where researchers developed a two-minute questionnaire that asked close friends and family members if they have noticed problems with memory or judgment. The survey asked “yes” or “no” questions about whether they have noticed such signs in loved ones as:

Survey results were then correlated with so-called biomarkers, like brain changes on brain scans or blood tests results, that are generally regarded as predictors of Alzheimer’s. The survey proved more accurate than standard word and memory tests like the mini-mental state exam, which doctors perform in their offices to look for early signs of Alzheimer’s.

Close friends and relatives know loved ones well and see them on a regular basis, so it is not surprising that they can pick up subtle changes in thinking or behavior over time. Traditional memory tests, in contrast, provide just a snapshot of a person’s mental state while they are sitting in the doctor’s office.

In addition, those with early Alzheimer’s often lack insight into their own thinking problems, so asking them about these problems is often not accurate.

“It’s not economically feasible to screen everyone for Alzheimer’s disease biomarkers,” said Dr. John C. Morris, director of the Charles F. and Joanne Knight Alzheimer’s Disease Research Center at Washington University. The questionnaire, he said, “gives us a brief and very low-cost alternative that takes a few minutes of the informant’s time to screen for dementia and thus identify those individuals who need follow-up evaluations to determine if there truly are signs of Alzheimer’s.”

If you suspect a family member or friend is having trouble with thinking and memory, bring it to the attention of their doctor. Alzheimer’s is just one of many causes of failing memory. And in some cases, such as medication side effects, memory loss may be reversible.

By, The Alzheimer’s Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.

Source: Washington University School of Medicine. Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC. “Relationship of dementia screening tests with biomarkers of Alzheimer’s disease”. Brain, online Sept. 10, 2010.

Add a Comment

Melvin R. Bielawski

October 29, 2010 at 12:03 am

Early detection of dementia/MCI (mind cognitive impairment)can be as simple as observing if a person has difficulty in remembering the day of the week or date and failure to recognize close relatives/friends. Early diagnosis and treatment, preferably by a neurologist, is critical in “delaying” the full impact of the loss of memory via available medications such as Aricept, Namenda, etc. to enhance the memory.

Denise Graab

October 29, 2010 at 6:23 am

Thank you for presenting the findings of this study from the Washington University School of Medicine. knows from research it conducted in August that family caregivers do struggle with the delayed diagnosis and lack of insight for their loved one’s stage of Alzheimer’s or dementia. Caring Steps & Stages helps address these concerns (and others) by providing family caregivers free stage-based guidance and support best matched to their specific needs. While this customizable resource is not a substitute for the consultation, diagnosis and advice of a doctor, it does help family caregivers navigate the overwhelming Alzheimer’s journey — from identifying what stage their loved one is in, to understanding what symptoms to expect and how to cope with them, week by week. We appreciate that you shared this resource with your readers: /articles/expect-youre-caregiving/

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