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- Talking to a Loved One With Alzheimer’s
- 10 Powerful Ways to Commemorate Alzheimer’s Awareness Month
- Making the Most of Mealtimes for People With Alzheimer’s
- Family Members Provide 100 Hours a Month of Unpaid Care for Alzheimer’s
- Alzheimer’s Caregivers Should Be Screened for Depression
- Alzheimer’s Care Costs Far More Than Heart Disease or Cancer Care
- Obesity at Midlife May Speed Alzheimer’s Onset
- Hello from my mom
- Easing the Behavior Problems of Alzheimer’s Without Drugs
- When Alzheimer’s Leads to Legal Wrangles
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- Daytime Sleepiness May Be Early Warning Sign of Alzheimer’s
- Alzheimer’s Disease Increases the Risk of Falls
- High Blood Sugar Tied to Memory Decline
- Blood Test for Alzheimer’s Gets Closer
- Worried About Your Memory? Alzheimer’s May Not Be to Blame
- Brain Changes of Menopause May Promote Alzheimer’s
- Predicting Who Will Get Alzheimer’s
- Personality Changes Are Not the Earliest Sign of Alzheimer’s
- Midlife Heart Problems Raise Alzheimer’s Risk
- Anemia Tied to Mild Cognitive Impairment Risk
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- Music May Ease the Anxiety of Alzheimer’s
- Experimental Alzheimer’s Drug, Intepirdine, Disappoints in Study
- An Eye Scan for Alzheimer’s?
- Drug to treat Alzheimer’s is Ranked Highest
- Patients Often Fail to Adhere to Alzheimer’s Drug Schedules
- Could Treatments for Diabetes Help Treat Alzheimer’s?
- Pharmacists Can Aid in Alzheimer’s Care
- Two-Drug Combo May Ease the Agitation of Alzheimer’s
- Are New, More Effective Alzheimer’s Drugs on the Horizon?
- Nasal Spray Shows Promise as Alzheimer’s Treatment
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- 2 Hours a Week of Exercise Can Boost Brain Health
- ‘Exergames,’ Which Combine Exercise and Games, May Benefit Brain Health
- Eat Fish, Fruit, Vegetables and Nuts for Brain Health
- Beet Compound Shows Promise Against Alzheimer’s
- A Single Night of Not Sleeping Tied to Alzheimer’s Brain Changes
- Should Alzheimer’s Patients Drink Coffee?
- Can a Salad a Day Help Keep Memory Sharp?
- Fitness in Midlife Tied to Lower Dementia Risk in Old Age
- Doctor’s Orders: Exercise for the Sake of Your Brain
- Positive Beliefs About Aging May Help Fend Off Alzheimer’s
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- Alzheimer’s Rates Could Double in Coming Decades
- Combining Care Program With Medication Reduces Alzheimer’s Symptoms By 750%
- Fisher Center Scientists make two new Significant Discoveries in the battle against Alzheimer’s
- Dementia Rates Are Slowing, but Alzheimer’s Cases Continue to Rise
- Fisher Center Scientists Create a Novel Imaging Technology Allowing the 3D Visualization of Brain Defects That Cause Alzheimer’s Disease
- Negative Beliefs About Aging Could Prime the Brain for Alzheimer’s
- Recognizing Faces Is a Challenge for Those With Alzheimer’s
- Fisher Center Scientists Discover Pathway That may Lead to Alzheimer’s Disease
- Brain Scans Move Closer to Early Alzheimer’s Diagnosis
- Can Vitamin E Slow Alzheimer’s Decline?
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- The Fisher Center for Alzheimer’s Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer’s Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer’s Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O’Neal, Joins the Fisher Center for Alzheimer’s Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
- Pat Summitt, legendary women’s basketball coach, dies at 64
- Celebrating the life of Nancy Reagan for her Impact on the Fight to end Alzheimer’s
- WRNN Interview
- Fisher Center’s 20th Anniversary Celebration and recent activities
- Featured on NASDAQ’s Billboard
- Online Chat on Reddit.com with Nobel Laureate Dr. Paul Greengard
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Predicting Who Will Get Alzheimer’s
It’s practically impossible today to predict if older adults with memory problems will go on to develop full-blown Alzheimer’s disease. But a study of more than 500 older men and women with memory problems suggests that certain biological features may help to accurately predict who will progress to Alzheimer’s.
For the study, Danish researchers studied 525 men and women, most in their late 60s, who had mild cognitive impairment, a clinical stage characterized by clear cognitive deficits not yet fully typical of Alzheimer’s disease but that often progresses to Alzheimer’s disease.In general, about half of those with mild cognitive impairment will go on to develop Alzheimer’s over the next three years.
For the study, volunteers completed the Mini-Mental State Examination, a 30-point questionnaire that takes five to 10 minutes to complete. Test takers are asked to answer a series of questions, including the time and place of the test, repeating a list of words, completing a math series and drawing various shapes. Any score from 24 to 30 generally indicates normal memory and thinking skills, while lower scores indicate impaired cognitive function.
Study participants also received an MRI scan of the brain. A shrinking brain is often a sign of Alzheimer’s disease, other studies have shown.
Finally, study participants had spinal fluid samples taken. The samples measured levels of various components, including the protein tau and the peptide beta-amyloid, that can signal the onset of Alzheimer’s disease.
During a follow-up period of two to three years, 38 percent of those in the study went on to develop Alzheimer’s disease.
The researchers came up with a fairly accurate assessment of who would go on to develop Alzheimer’s disease. They found, for example, that after three years, only 4 percent of patients with MMSE scores of 29 who had normal biological test results on spinal fluid proteins and brain size went on to develop Alzheimer’s. In contrast, as many as 89 percent of those with MMSE scores of 24 or less and abnormal spinal fluid markers progressed to Alzheimer’s disease.
After one year, less than 1 percent of those with normal biomarkers and high MMSE scores went on to develop Alzheimer’s. That compared to 26 percent of those with abnormal biomarkers and low MMSE scores.
The authors say their predictive models “could be easily implemented in daily practice”and enable doctors “to start treatment or provide more accurate patient management.” Determining who will likely not progress to full-blown Alzheimer’s can also be valuable for families, patients and clinicians. They intend to follow up with additional research and develop a web-based application for doctors.
By www.ALZinfo.org, The Alzheimer’s Information Site. Reviewed by Marc Flajolet, Ph.D., Fisher Center for Alzheimer’s Research Foundation at The Rockefeller University.
Source: Ingrid S. van Maurik, MSc; Marissa D. Swan, PhD; Betty M. Tijms, PhD; et al: “Interpreting Biomarker Results in Individual Patients With Mild Cognitive Impairment in the Alzheimer’s Biomarkers in Daily Practice (ABIDE) Project.” JAMA Neurology, Oct. 16, 2017